These days, the first round of the NCAA tournament is actually what’s known as the first four, where no upsets can occur, with the real stuff and the actual best of 64 beginning in the second round. To this day, no number one seed has ever lost to a #16 seeded team, but we’ve had six upsets of a 15th seed over a number 2, including twice last season, with Duke losing to Lehigh and Missouri dropping a game to Norfolk State